Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-ÐºB axis.

Zeng, Xin; Yang, Meihua; Ye, Tingbo; Feng, Jinmei; Xu, Xiaohui; Yang, Huaan; Wang, Xin; Bao, Liming; Li, Rui; Xue, Bingqian; Zang, Jinbao; Huang, Yi

Zeng, Xin; Yang, Meihua; Ye, Tingbo; Feng, Jinmei; Xu, Xiaohui; Yang, Huaan; Wang, Xin; Bao, Liming; Li, Rui; Xue, Bingqian; Zang, Jinbao; Huang, Yi.

Afiliação

Zeng X; Institute of Paediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China
Yang M; Departments of Neurology, Washington University School of Medicine and Barnes-Jewish Hospital, Saint Louis, 63110, MO, USA.
Ye T; Department of Laboratory Medicine, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Feng J; Institute of Paediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China
Xu X; Institute of Paediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China
Yang H; Department of Urologic Surgery, Yubei District People's Hospital, Chongqing, 401120, China.
Wang X; Ministry of Education Key Laboratory of Molecular Biology for Infectious Diseases, Chongqing Medical University, Chongqing, 40016, China.
Bao L; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA.
Li R; Department of Laboratory Medicine, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Xue B; Department of Laboratory Medicine, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
Zang J; Institute of Paediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China
Huang Y; Institute of Paediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China

Free Radic Biol Med ; 202: 46-61, 2023 06.

Article em En | MEDLINE | ID: mdl-36990300

Assuntos

Gastrite; NADH NADPH Oxirredutases; NF-kappa B; Animais; Humanos; Camundongos; Gastrite/genética; Heme Oxigenase-1/genética; Heme Oxigenase-1/metabolismo; Inflamassomos/genética; Inflamassomos/metabolismo; Interleucina-33; Metaplasia; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/genética; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Domínio Pirina; Espécies Reativas de Oxigênio/metabolismo; NADH NADPH Oxirredutases/genética

Palavras-chave

Chronic atrophic gastritis (CAG); GRIM-19; IL-33; NLRP3 inflammasome; SPEM

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Gastrite / NADH NADPH Oxirredutases Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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