Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases.

Lampe, George D; King, Rebeca T; Halpin-Healy, Tyler S; Klompe, Sanne E; Hogan, Marcus I; Vo, Phuc Leo H; Tang, Stephen; Chavez, Alejandro; Sternberg, Samuel H

Lampe, George D; King, Rebeca T; Halpin-Healy, Tyler S; Klompe, Sanne E; Hogan, Marcus I; Vo, Phuc Leo H; Tang, Stephen; Chavez, Alejandro; Sternberg, Samuel H.

Afiliação

Lampe GD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
King RT; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Halpin-Healy TS; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Klompe SE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Hogan MI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Vo PLH; Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Tang S; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Chavez A; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Sternberg SH; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.

Nat Biotechnol ; 42(1): 87-98, 2024 Jan.

Article em En | MEDLINE | ID: mdl-36991112

Assuntos

Sistemas CRISPR-Cas; Transposases; Humanos; Sistemas CRISPR-Cas/genética; Transposases/genética; Plasmídeos; DNA; Genoma; Edição de Genes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transposases / Sistemas CRISPR-Cas Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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