Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics.

Chen, Yangyang; Tan, Lun; Gao, Jing; Lin, Congcong; Wu, Fengbo; Li, Yang; Zhang, Jifa

Chen, Yangyang; Tan, Lun; Gao, Jing; Lin, Congcong; Wu, Fengbo; Li, Yang; Zhang, Jifa.

Afiliação

Chen Y; Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Tan L; Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Gao J; Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Lin C; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, China.
Wu F; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: Fbwu2013@scu.edu.cn.
Li Y; Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: 1617664@qq.com.
Zhang J; Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: zjf298257@163.com.

Eur J Med Chem ; 252: 115306, 2023 Apr 05.

Article em En | MEDLINE | ID: mdl-36996714

Assuntos

Glutaminase

Palavras-chave

Glutaminase-1; Small-molecule inhibitors; Structure-activity relationships (SARs); X-ray co-crystal structure analyses

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glutaminase Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glutaminase Idioma: En Ano de publicação: 2023 Tipo de documento: Article