Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcÎ³RIIb binding and retention of super-agonist activity.

Chenoweth, Alicia M; Esparon, Sandra; Wines, Bruce D; Schuurman, Janine; Labrijn, Aran F; Hogarth, P Mark

Chenoweth, Alicia M; Esparon, Sandra; Wines, Bruce D; Schuurman, Janine; Labrijn, Aran F; Hogarth, P Mark.

Afiliação

Chenoweth AM; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
Esparon S; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Wines BD; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
Schuurman J; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
Labrijn AF; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Hogarth PM; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.

Immunol Cell Biol ; 101(7): 657-662, 2023 08.

Article em En | MEDLINE | ID: mdl-36997299

Assuntos

Imunoglobulina G; Receptores de IgG; Humanos; Receptores de IgG/metabolismo; Anticorpos Monoclonais/uso terapêutico; Mutação/genética

Palavras-chave

CD28 super-agonism; antibody Fc engineering; cytokine release syndrome; inhibitory FcR; monoclonal antibody therapeutics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Receptores de IgG Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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