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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.
Mertens, Sander; Huismans, Maarten A; Verissimo, Carla S; Ponsioen, Bas; Overmeer, Rene; Proost, Natalie; van Tellingen, Olaf; van de Ven, Marieke; Begthel, Harry; Boj, Sylvia F; Clevers, Hans; Roodhart, Jeanine M L; Bos, Johannes L; Snippert, Hugo J G.
Afiliação
  • Mertens S; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Huismans MA; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Verissimo CS; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Ponsioen B; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Overmeer R; Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
  • Proost N; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
  • van Tellingen O; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands; Division of Clinical Pharmacology, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
  • van de Ven M; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
  • Begthel H; Oncode Institute, Hubrecht Institute-KNAW, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Boj SF; Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
  • Clevers H; Oncode Institute, Hubrecht Institute-KNAW, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Roodhart JML; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Bos JL; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Snippert HJG; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: h.j.g.snippert@umcutrecht.nl.
Cell Rep ; 42(4): 112324, 2023 04 25.
Article em En | MEDLINE | ID: mdl-37000626
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias do Colo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias do Colo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article