An emerging class of nucleic acid-sensing regulators in bacteria: WYL domain-containing proteins.
Curr Opin Microbiol
; 74: 102296, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37027901
ABSTRACT
Transcriptional regulation plays a central role in adaptation to changing environments for all living organisms. Recently, proteins belonging to a novel widespread class of bacterial transcription factors have been characterized in mycobacteria and Proteobacteria. Those multidomain proteins carry a WYL domain that is almost exclusive to the domain of bacteria. WYL domain-containing proteins act as regulators in different cellular contexts, including the DNA damage response and bacterial immunity. WYL domains have an Sm-like fold with five antiparallel ß-strands arranged into a ß-sandwich preceded by an α-helix. A common feature of WYL domains is their ability to bind nucleic acids that regulate their activity. In this review, we discuss recent progress made toward the understanding of WYL domain-containing proteins as transcriptional regulators, their structural features, and molecular mechanisms, as well as their functional roles in bacterial physiology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Ácidos Nucleicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article