Novel hits for autosomal dominated polycystic kidney disease (ADPKD) targeting derived by <i>in silico</i> screening on ZINC-15 natural product database.

Nejabat, Mojgan; Hadizadeh, Farzin; Nejabat, Masoud; Rajabi, Omid

Novel hits for autosomal dominated polycystic kidney disease (ADPKD) targeting derived by in silico screening on ZINC-15 natural product database.

Nejabat, Mojgan; Hadizadeh, Farzin; Nejabat, Masoud; Rajabi, Omid.

Afiliação

Nejabat M; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hadizadeh F; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Nejabat M; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Rajabi O; Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

J Biomol Struct Dyn ; 42(2): 885-902, 2024.

Article em En | MEDLINE | ID: mdl-37029756

Assuntos

Rim Policístico Autossômico Dominante; Sesquiterpenos; Humanos; Rim Policístico Autossômico Dominante/tratamento farmacológico; Rim Policístico Autossômico Dominante/genética; PPAR gama; Sesquiterpenos/uso terapêutico; Zinco; Proteínas Serina-Treonina Quinases

Palavras-chave

ADPKD; Autosomal dominant polycystic kidney disease; MD simulation; ZINC; molecular docking; natural products; sesquiterpene coumarins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Rim Policístico Autossômico Dominante Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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