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New antioxidant therapy for hard-to-heal neuroischaemic diabetic foot ulcers with deep exposure.
Pérez-Zabala, Elena; Basterretxea, Andima; Castro, Begoña; Aizpuru, Alfonso; Arancon, Jose Antonio; Moreno, Carla; Zubizarreta, Arrate; Larizgoitia, Zohartze; Ysa, August; Lobato, Marta; Larrazabal, Ainara.
Afiliação
  • Pérez-Zabala E; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Basterretxea A; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Castro B; Histocell S.L., Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Aizpuru A; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Arancon JA; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Moreno C; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Zubizarreta A; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Larizgoitia Z; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
  • Ysa A; Vascular Surgery Department, Cruces University Hospital, Bizkaia, Spain.
  • Lobato M; Vascular Surgery Department, Cruces University Hospital, Bizkaia, Spain.
  • Larrazabal A; Hospital-at-Home Department, Cruces University Hospital, Bizkaia, Spain.
J Wound Care ; 32(4): 238-246, 2023 Apr 02.
Article em En | MEDLINE | ID: mdl-37029973
OBJECTIVE: To evaluate the clinical efficacy of a new antioxidant therapy for the treatment of complex neuroischaemic diabetic foot ulcers (DFUs). METHOD: A prospective case series study has been conducted in patients with complex neuroischaemic DFUs after transmetatarsal amputation. DFUs were locally treated with an antioxidant dressing twice a week for the first two weeks, and then once a week until the end of the study or complete wound closure. Patients were followed-up for eight weeks and assessed weekly to analyse wound outcome. Primary outcomes were the wound closure ratio and percentage of granulation tissue; secondary outcomes were parameters related to wound management, namely, presence of non-viable tissue in the wound bed, levels of maceration and exudates, presence of erythema and pain. RESULTS: A total of 20 patients were included with a mean baseline wound area of 20.4cm2. At 8 weeks, the mean reduction in wound area was 88.1% (p<0.0001) and complete closure was observed in 33% of cases. In addition, there was a mean increase of 94.7% in granulation tissue in the wound bed (p<0.0001). Furthermore, the therapy was associated with a significant percentage reduction in wounds with non-viable tissue, good exudate management, and the maintenance of low levels of maceration, erythema and pain. CONCLUSION: The new antioxidant therapy was associated with good clinical outcomes in large hard-to-heal neuroischaemic DFUs, with significant wound area reduction and granulation tissue formation. The therapy was also found to be safe and perform well from a practical perspective.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pé Diabético / Diabetes Mellitus Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pé Diabético / Diabetes Mellitus Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article