Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant <i>Candida albicans</i>.

Li, Zhuang; Huang, Yahui; Tu, Jie; Yang, Wanzhen; Liu, Na; Wang, Wei; Sheng, Chunquan

Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans.

Li, Zhuang; Huang, Yahui; Tu, Jie; Yang, Wanzhen; Liu, Na; Wang, Wei; Sheng, Chunquan.

Afiliação

Li Z; State Key Laboratory of Bioengineering Reactor, and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China.
Huang Y; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, People's Republic of China.
Tu J; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, People's Republic of China.
Yang W; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, People's Republic of China.
Liu N; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, People's Republic of China.
Wang W; State Key Laboratory of Bioengineering Reactor, and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China.
Sheng C; Department of Pharmacology and Toxicology, College of Pharmacy, and BIO5 Institute, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona 85721-0207, United States.

J Med Chem ; 66(8): 5950-5964, 2023 04 27.

Article em En | MEDLINE | ID: mdl-37037787

Assuntos

Antifúngicos; Candidíase; Humanos; Antifúngicos/farmacologia; Fluconazol/farmacologia; Candida albicans; Proteínas Nucleares; Inibidores de Histona Desacetilases/farmacologia; Sinergismo Farmacológico; Farmacorresistência Fúngica; Testes de Sensibilidade Microbiana; Fatores de Transcrição; Candidíase/tratamento farmacológico; Proteínas de Ciclo Celular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candidíase / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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