An ERK1/2-driven RNA-binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene.

Azman, Muhammad S; Alard, Emilie L; Dodel, Martin; Capraro, Federica; Faraway, Rupert; Dermit, Maria; Fan, Wanling; Chakraborty, Alina; Ule, Jernej; Mardakheh, Faraz K

Azman, Muhammad S; Alard, Emilie L; Dodel, Martin; Capraro, Federica; Faraway, Rupert; Dermit, Maria; Fan, Wanling; Chakraborty, Alina; Ule, Jernej; Mardakheh, Faraz K.

Afiliação

Azman MS; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Alard EL; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Dodel M; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Capraro F; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Faraway R; Randall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Dermit M; The Francis Crick Institute, London, UK.
Fan W; Dementia Research Institute, King's College London, London, UK.
Chakraborty A; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Ule J; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Mardakheh FK; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.

EMBO J ; 42(11): e110902, 2023 06 01.

Article em En | MEDLINE | ID: mdl-37039106

Assuntos

Genes ras; Neoplasias Pancreáticas; Humanos; Sistema de Sinalização das MAP Quinases; Proteômica; Fosfoproteínas/metabolismo; RNA Ribossômico/metabolismo; RNA/metabolismo; Transformação Celular Neoplásica/genética; Ribossomos/genética; Ribossomos/metabolismo; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Nucleolina

Palavras-chave

Nucleolin; RAS; RNA-binding proteins; pancreatic ductal adenocarcinoma; ribosome biogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Genes ras Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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