Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations.

Zhang, Cheng; Bye, Jordan W; Lui, Lok H; Zhang, Hongyu; Hales, John; Brocchini, Steve; Curtis, Robin A; Dalby, Paul A

Zhang, Cheng; Bye, Jordan W; Lui, Lok H; Zhang, Hongyu; Hales, John; Brocchini, Steve; Curtis, Robin A; Dalby, Paul A.

Afiliação

Zhang C; Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, U.K.
Bye JW; School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, Manchester M13 9PL, U.K.
Lui LH; UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, U.K.
Zhang H; Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, U.K.
Hales J; Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, U.K.
Brocchini S; UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, U.K.
Curtis RA; School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, Manchester M13 9PL, U.K.
Dalby PA; Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, U.K.

Mol Pharm ; 20(5): 2650-2661, 2023 05 01.

Article em En | MEDLINE | ID: mdl-37040431

Assuntos

Fragmentos Fab das Imunoglobulinas; Entropia; Estabilidade Proteica

Palavras-chave

aggregation; concentration; crowding effect; dynamic light scattering (DLS); entropy change (â³Svh); fab; mechanistic model; melting temperature (Tm)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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