Inhibition of Soluble Epoxide Hydrolase Activity by Components of Glycyrrhiza uralensis.
Int J Mol Sci
; 24(7)2023 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-37047457
ABSTRACT
Soluble epoxide hydrolase (sEH) is a target enzyme for the treatment of inflammation and cardiovascular disease. A Glycyrrhiza uralensis extract exhibited ~50% inhibition of sEH at 100 µg/mL, and column chromatography yielded compounds 1-11. Inhibitors 1, 4-6, 9, and 11 were non-competitive; inhibitors 3, 7, 8, and 10 were competitive. The IC50 value of inhibitor 10 was below 2 µM. Molecular simulation was used to identify the sEH binding site. Glycycoumarin (10) requires further evaluation in cells and animals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glycyrrhiza uralensis
/
Epóxido Hidrolases
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article