Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease.
Platelets
; 34(1): 2200860, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37070954
What is the context?â Clopidogrel combined with aspirin is widely used in coronary artery disease (CAD) patients, while some patients exhibit high platelet activity when receiving the combined treatment.â Current environmental and genetic factors could only explain part of the variability in clopidogrel efficacy.â Human platelets harbor abundant miRNAs which might affect clopidogrel efficacy by regulating the expression of key proteins in the clopidogrel antiplatelet signaling pathway.What is new?â We found that decreased platelet miR-199a-5p level was associated with high on-clopidogrel platelet reactivity.â Overexpression of miR-199a-5p significantly down-regulated the expression of VASP protein in cultured cells.What is the impact?â The current study provided new insights into the exploration of interindividual variability in clopidogrel response from the perspective of miR-199a-5p and VASP interaction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
MicroRNAs
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Intervenção Coronária Percutânea
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article