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Study on antibody Fc-glycosylation for optimal effector functions.
Shivatare, Vidya S; Chuang, Po-Kai; Tseng, Tzu-Hao; Zeng, Yi-Fang; Huang, Han-Wen; Veeranjaneyulu, Gannedi; Wu, Han-Chung; Wong, Chi-Huey.
Afiliação
  • Shivatare VS; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Chuang PK; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Tseng TH; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Zeng YF; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Huang HW; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Veeranjaneyulu G; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
  • Wu HC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
  • Wong CH; Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. wong@scripps.edu.
Chem Commun (Camb) ; 59(37): 5555-5558, 2023 May 04.
Article em En | MEDLINE | ID: mdl-37071468
ABSTRACT
A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant enhancement in antibody effector functions, including binding to different Fc receptors and ADCC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Fragmentos Fc das Imunoglobulinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Fragmentos Fc das Imunoglobulinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article