Clinical characteristics of obese patients with adult-onset Still's disease. Data from a large multicentre cohort.
Joint Bone Spine
; 90(5): 105576, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37080283
ABSTRACT
OBJECTIVES:
To evaluate the impact of obesity in patients with adult-onset Still's disease (AOSD) and to assess their clinical characteristics and disease outcomes.METHODS:
The clinical features of AOSD patients with a body mass index (BMI)≥30 were assessed among those included in the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort.RESULTS:
Out of 139 AOSD patients, who had BMI registered in our database, 26 (18.7%) had a BMI≥30. A lower rate of sore throat (P<0.05), pericarditis (P<0.05), and pleuritis (P<0.05) was shown in obese patients. Additionally, obese patients showed higher values of C-reactive protein (CRP) (P<0.05) and ferritin (P<0.05) than others. Furthermore, obese patients were characterised by biologic disease-modifying antirheumatic drug (bDMARD) failure in subsequent follow-up (P<0.05). They also presented higher rate of comorbidity than non-obese patients (P<0.05). Finally, obesity predicted the presence of a chronic disease course in both univariate (HR 1.72, 95%CI 1.03-2.51, P<0.05) and multivariate analyses (HR 1.85, 95%CI 1.45-2.89, P<0.05). Obesity was also a significant predictor of bDMARD failure in AOSD patients in both univariate (HR 3.03, 95%CI 1.42-6.45, P<0.01) and multivariate analyses (HR 3.59, 95%CI 1.55-8.27, P<0.01).CONCLUSION:
Obese patients at the time of diagnosis of the disease were characterised by a lower prevalence of sore throat, serositis, as well as by higher values of CRP and ferritin. Obesity was also a predictive factor for a chronic disease course and bDMARD failure, thus highlighting a subset of patients with AOSD to be carefully managed.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Still de Início Tardio
/
Antirreumáticos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article