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Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study.
Maoz, Sabrina L; Wang, Eric W; Hwang, Peter H; Choby, Garret; Kuan, Edward C; Fleseriu, Cara M; Chan, Erik P; Adappa, Nithin D; Geltzeiler, Mathew; Getz, Anne E; Humphreys, Ian M; Le, Christopher H; Abuzeid, Waleed M; Chang, Eugene H; Jafari, Aria; Kingdom, Todd T; Kohanski, Michael A; Lee, Jivianne K; Lazor, Jillian W; Nabavizadeh, Ali; Nayak, Jayakar V; Palmer, James N; Patel, Zara M; Pinheiro-Neto, Carlos D; Resnick, Adam C; Smith, Timothy L; Snyderman, Carl H; St John, Maie A; Storm, Phillip B; Suh, Jeffrey D; Wang, Marilene B; Sim, Myung S; Beswick, Daniel M.
Afiliação
  • Maoz SL; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang EW; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Hwang PH; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Choby G; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Kuan EC; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Fleseriu CM; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Chan EP; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Adappa ND; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Geltzeiler M; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Getz AE; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Humphreys IM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Le CH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Abuzeid WM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Chang EH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Jafari A; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Kingdom TT; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Kohanski MA; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Lee JK; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Lazor JW; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Nabavizadeh A; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Nayak JV; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Palmer JN; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Patel ZM; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Pinheiro-Neto CD; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Resnick AC; Center for Data Driven Discovery, Children's Hospital of Philadelphia, Pittsburgh, Pennsylvania, USA.
  • Smith TL; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Snyderman CH; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • St John MA; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Storm PB; Center for Data Driven Discovery, Children's Hospital of Philadelphia, Pittsburgh, Pennsylvania, USA.
  • Suh JD; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang MB; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Sim MS; Department of Medicine-Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
  • Beswick DM; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
Int Forum Allergy Rhinol ; 13(11): 2030-2042, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37082883
BACKGROUND: Quality of life (QOL) for individuals with sinonasal malignancy (SNM) is significantly under-studied, yet it is critical for counseling and may impact treatment. In this study we evaluated how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year posttreatment time frame. METHODS: Patients with SNM who underwent definitive treatment with curative intent were enrolled in a prospective, multisite, longitudinal observational study. QOL was assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pretreatment baseline and multiple follow-ups through 5 years posttreatment. Multivariable modeling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL. RESULTS: One hundred ninety-four patients with SNM were analyzed. All QOL indices were impaired at pretreatment baseline and improved after treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6 to 9 months posttreatment. Patients who underwent open compared with endoscopic tumor resection had worse generalized QOL (p < 0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p < 0.001; UWQOL Physical dimension, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01). CONCLUSION: Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves after treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL posttreatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article