Highly efficient α-arylation of aryl ketones with aryl chlorides by using bulky imidazolylidene-ligated oxazoline palladacycles.
Org Biomol Chem
; 21(18): 3858-3862, 2023 May 10.
Article
em En
| MEDLINE
| ID: mdl-37093227
ABSTRACT
α-Aryl derivatives of carbonyl compounds are important building blocks. Herein, we presented an efficient catalytic system for the α-arylation of aryl ketones with inactive aryl chlorides by firstly using N,N'-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene (IPr)-ligated chiral oxazoline palladacycles, and tolerated a wide range of substrates at low catalyst loadings, leading to the desired products in good to excellent yields.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article