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Cortico-limbic disruption, material-specificity, and deficits in cognitive-affective theory of mind.
Singh, Varsha; Grewal, Kirat S; Vibha, Deepti; Singh, Rajesh K; Ramanujam, Bhargavi; Nehra, Ashima; Chandra, Sarat P; Gaikwad, Shailesh; Babu, Indupriya; Tripathi, Manjari.
Afiliação
  • Singh V; Psychology, Department of Humanities and Social Sciences, Indian Institute of Technology Delhi (IIT), New Delhi, 110016, India.
  • Grewal KS; Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
  • Vibha D; Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
  • Singh RK; Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
  • Ramanujam B; Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
  • Nehra A; Neuropsychology, Neurosciences Centre, All India Institute of Medical Sciences (AIIMS), Delhi, New Delhi 110029, India.
  • Chandra SP; Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), Delhi, New Delhi 110029, India.
  • Gaikwad S; Department of Neuroimaging Interventional Neuroradiology, All India Institute of Medical Sciences (AIIMS), Delhi, New Delhi 110029, India.
  • Babu I; The UQIDAR Joint Ph.D. program, Indian Institute of Technology Delhi (IIT), New Delhi 110016.India.
  • Tripathi M; Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
Brain Commun ; 5(2): fcad100, 2023.
Article em En | MEDLINE | ID: mdl-37101833
The Theory of Mind deficit due to cognitive-affective disintegration is a poorly understood cognitive consequence of cortical and subcortical disruption in right temporal lobe epilepsy. Following Marr's trilevel approach, we used the material-specific processing model to understand the Theory of Mind deficit in drug-resistant epilepsy (N = 30). We examined pre- and post-surgery changes in first-order (somatic-affective, non-verbal component) and second-order Theory of Mind (cognitive-verbal component) in three groups formed using: (i) seizure side (right versus left), (ii) right temporal epilepsy (right temporal lobe epilepsy versus non-right temporal lobe epilepsy), and (iii) right temporal lobe epilepsy with amygdalohippocampectomy (right temporal lobe epilepsy versus left temporal lobe epilepsy amygdalohippocampectomy versus non-amygdalohippocampectomy). We observed a marked deficit in the first-order Theory of Mind in the right temporal lobe amygdalohippocampectomy group; we mapped this deficit to decline in the non-verbal component of Theory of Mind (somatic-affective component). Preliminary results support using a material-specific processing model to understand the Theory of Mind deficits in right temporal lobe epilepsy amygdalohippocampectomy. Malleability of verbal processing in presence of deterioration of non-verbal processing might have clinical relevance for post-surgery recovery in right temporal lobe epilepsy amygdalohippocampectomy. Documenting the material-specific nature of deficits (verbal versus non-verbal) in non-western, linguistically, and socioeconomically diverse country enables us to understand the problem of heterogeneity in post-surgery cognitive consequences in the right amygdalohippocampectomy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article