An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically modulated.

Lind, Simon; Wu, Yanling; Sundqvist, Martina; Forsman, Huamei; Dahlgren, Claes

Lind, Simon; Wu, Yanling; Sundqvist, Martina; Forsman, Huamei; Dahlgren, Claes.

Afiliação

Lind S; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Wu Y; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Sundqvist M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Forsman H; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Dahlgren C; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address: Claes.Dahlgren@microbio.gu.se.

Cell Signal ; 107: 110687, 2023 07.

Article em En | MEDLINE | ID: mdl-37105507

Assuntos

Cálcio; Neutrófilos; Neutrófilos/metabolismo; Cálcio/metabolismo; Ácidos Graxos não Esterificados/metabolismo; NADP/metabolismo; Ionomicina/metabolismo; Íons/metabolismo; Trifosfato de Adenosina/metabolismo; Oxirredutases; NADPH Oxidases/metabolismo; Superóxidos/metabolismo

Palavras-chave

Allosteric modulation; FFA2R; Intracellular signaling; NADPH-oxidase; Receptor transactivation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Neutrófilos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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