Selective Hepatic <i>Cbs</i> Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet.

Lambooy, Sebastiaan; Heida, Andries; Joschko, Christian; Nakladal, Dalibor; van Buiten, Azuwerus; Kloosterhuis, Niels; Huijkman, Nicolette; Gerding, Albert; van de Sluis, Bart; Henning, Robert; Deelman, Leo

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet.

Lambooy, Sebastiaan; Heida, Andries; Joschko, Christian; Nakladal, Dalibor; van Buiten, Azuwerus; Kloosterhuis, Niels; Huijkman, Nicolette; Gerding, Albert; van de Sluis, Bart; Henning, Robert; Deelman, Leo.

Afiliação

Lambooy S; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Heida A; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Joschko C; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Nakladal D; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
van Buiten A; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Kloosterhuis N; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Huijkman N; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Gerding A; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
van de Sluis B; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Henning R; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Deelman L; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.

Int J Mol Sci ; 24(8)2023 Apr 10.

Article em En | MEDLINE | ID: mdl-37108182

Assuntos

Hiper-Homocisteinemia; Hepatopatia Gordurosa não Alcoólica; Camundongos; Animais; Hepatopatia Gordurosa não Alcoólica/genética; Espécies Reativas de Oxigênio; Dieta Ocidental/efeitos adversos; Peróxido de Hidrogênio; Camundongos Knockout; Fígado; Cistationina beta-Sintase/genética; Dieta Hiperlipídica/efeitos adversos; Camundongos Endogâmicos C57BL; Modelos Animais de Doenças

Palavras-chave

NAFLD; cystathionine-ß-synthase; high-fat diet; hydrogen sulfide; hyperhomocysteinemia; knockout mice; liver damage; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiper-Homocisteinemia / Hepatopatia Gordurosa não Alcoólica Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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