Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between G&#945;q and ß-Arrestin through BRET Assays and Molecular Docking.

Wang, Dongxue; Yao, Yunjin; Wang, Shiqi; Hou, Yifei; Zhao, Lanxue; Wang, Hao; Chen, Hongzhuan; Xu, Jianrong

Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and ß-Arrestin through BRET Assays and Molecular Docking.

Wang, Dongxue; Yao, Yunjin; Wang, Shiqi; Hou, Yifei; Zhao, Lanxue; Wang, Hao; Chen, Hongzhuan; Xu, Jianrong.

Afiliação

Wang D; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yao Y; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang S; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Hou Y; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhao L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wang H; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chen H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xu J; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Int J Mol Sci ; 24(8)2023 Apr 16.

Article em En | MEDLINE | ID: mdl-37108518

Assuntos

Acetilcolina; Receptor Muscarínico M1; Humanos; beta-Arrestinas/metabolismo; Simulação de Acoplamento Molecular; Receptor Muscarínico M1/metabolismo; Cloreto de (4-(m-Clorofenilcarbamoiloxi)-2-butinil)trimetilamônio; Pilocarpina/farmacologia; Proteínas de Ligação ao GTP/metabolismo; beta-Arrestina 2/metabolismo; beta-Arrestina 1/metabolismo; Transferência de Energia; Células HEK293

Palavras-chave

BRET; Gαq; M1 muscarinic acetylcholine receptor; molecular docking; signaling bias; ß-arrestin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolina / Receptor Muscarínico M1 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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