Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel.

Elverson, Kathleen; Warwicker, Jim; Freeman, Sally; Manson, Forbes

Elverson, Kathleen; Warwicker, Jim; Freeman, Sally; Manson, Forbes.

Afiliação

Elverson K; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Warwicker J; Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK.
Freeman S; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Manson F; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.

Molecules ; 28(8)2023 Apr 08.

Article em En | MEDLINE | ID: mdl-37110551

Assuntos

Canais de Cloreto; Epitélio Pigmentado da Retina; Humanos; Bestrofinas/metabolismo; Canais de Cloreto/genética; Canais de Cloreto/metabolismo; Tadalafila; Células HEK293; Mutação; Epitélio Pigmentado da Retina/metabolismo; Proteínas de Transporte Vesicular/genética

Palavras-chave

4PBA; COPII; FDA-approved; IRDs; bestrophin; tadalafil; virtual docking; whole-cell patch-clamp

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cloreto / Epitélio Pigmentado da Retina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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