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Head-to-Head Comparison between [68Ga]Ga-DOTA.SA.FAPi and [18F]F-FDG PET/CT Imaging in Patients with Breast Cancer.
Ballal, Sanjana; Yadav, Madhav P; Roesch, Frank; Wakade, Nicky; Raju, Shobhana; Sheokand, Parvind; Mishra, Prashant; Moon, Euy Sung; Tripathi, Madhavi; Martin, Marcel; Bal, Chandrasekhar.
Afiliação
  • Ballal S; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Yadav MP; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Roesch F; Department of Chemistry-TRIGA Site, Johannes Gutenberg University, 55099 Mainz, Germany.
  • Wakade N; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Raju S; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Sheokand P; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Mishra P; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Moon ES; Department of Chemistry-TRIGA Site, Johannes Gutenberg University, 55099 Mainz, Germany.
  • Tripathi M; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Martin M; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Bal C; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Pharmaceuticals (Basel) ; 16(4)2023 Mar 31.
Article em En | MEDLINE | ID: mdl-37111277
This study aimed to compare the diagnostic performance of [68Ga]Ga-DOTA.SA.FAPi with that of [18F]F-FDG PET/CT in detecting primary and metastatic lesions of breast cancer. [18F]F-FDG and [68Ga]Ga-DOTA.SA.FAPi PET/CT scans of histologically proven breast cancer patients were compared according to patient-based and lesion-based analysis. Forty-seven patients with a mean age of 44.8 ± 9.9 years (range: 31-66 years) were evaluated. A total of 85% of patients had invasive ductal carcinoma, and 15% had invasive lobular carcinoma. The tracer uptake [SULpeak, SULavg, and the median tumor-to-background ratio (TBR)] was significantly higher in [68Ga]Ga-DOTA.SA.FAPi than with [18F]F-FDG PET/CT for lymph nodes, pleural metastases, and liver lesions (p < 0.05). However, for brain metastasis, only the median TBR was significantly higher (p < 0.05) compared to [18F]F-FDG. In patient-based analysis the sensitivity of [68Ga]Ga-DOTA.SA.FAPi PET/CT was higher, but not significant than that of [18F]F-FDG PET/CT in the detection of both primary tumors and metastatic lesions. According to lesion-based analysis, on diagnostic CT, 47 patients had 44 primary tumors, 248 lymph nodes, 15 pleural, 88 liver, and 42 brain metastases. [68Ga]Ga-DOTA.SA.FAPi scan identified more abnormal lesions than [18F]F-FDG in all the primary and metastatic sites with a maximum marked difference in the primary site [88.6% vs. 81.8%; p-0.001], lymph nodes [89.1% vs. 83.8%; p-0.0001], pleural metastases [93.3% vs. 73%; p-0.096] and brain metastasis [100% vs. 59.5%; p-0.0001]. [68Ga]Ga-DOTA.SA.FAPi PET/CT was superior to [18F]F-FDG PET/CT in the imaging of breast cancers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article