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Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders.
Kang, Matthew J Y; Eratne, Dhamidhu; Dobson, Hannah; Malpas, Charles B; Keem, Michael; Lewis, Courtney; Grewal, Jasleen; Tsoukra, Vivian; Dang, Christa; Mocellin, Ramon; Kalincik, Tomas; Santillo, Alexander F; Zetterberg, Henrik; Blennow, Kaj; Stehmann, Christiane; Varghese, Shiji; Li, Qiao-Xin; Masters, Colin L; Collins, Steven; Berkovic, Samuel F; Evans, Andrew; Kelso, Wendy; Farrand, Sarah; Loi, Samantha M; Walterfang, Mark; Velakoulis, Dennis.
Afiliação
  • Kang MJY; Neuropsychiatry, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Eratne D; Melbourne Neuropsychiatry Centre & Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.
  • Dobson H; Alfred Mental and Addiction Health, Alfred Health, Melbourne, VIC, Australia.
  • Malpas CB; Neuropsychiatry, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Keem M; Melbourne Neuropsychiatry Centre & Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.
  • Lewis C; Neuropsychiatry, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Grewal J; Alfred Mental and Addiction Health, Alfred Health, Melbourne, VIC, Australia.
  • Tsoukra V; Department of Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Dang C; Melbourne School of Psychological Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Mocellin R; Neuropsychiatry, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Kalincik T; Melbourne Neuropsychiatry Centre & Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.
  • Santillo AF; Neuropsychiatry, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Zetterberg H; Alfred Mental and Addiction Health, Alfred Health, Melbourne, VIC, Australia.
  • Blennow K; Department of Neurology, Evangelismos Hospital, Athens, Greece.
  • Stehmann C; National Ageing Research Institute, University of Melbourne, Parkville, VIC, Australia.
  • Varghese S; Delmont Private Hospital, Glen Iris, VIC, Australia.
  • Li QX; Department of Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Masters CL; Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Collins S; Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Berkovic SF; Memory Clinic, Skåne University Hospital, Malmo, Sweden.
  • Evans A; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Kelso W; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Farrand S; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  • Loi SM; UK Dementia Research Institute at UCL, London, UK.
  • Walterfang M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Velakoulis D; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Acta Neuropsychiatr ; 36(1): 17-28, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37114460
ABSTRACT

OBJECTIVE:

People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.

METHODS:

We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.

RESULTS:

Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.

CONCLUSIONS:

CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article