Relationship of Vascular Endothelial Growth Factor C, a Lymphangiogenesis Modulator, With Edema Formation, Congestion and Outcomes in Acute Heart Failure.
J Card Fail
; 29(12): 1629-1638, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37121266
ABSTRACT
BACKGROUND:
Although vascular endothelial growth factor C (VEGF-C) is a known lymphangiogenesis modulator, its relationship with congestion formation and outcomes in acute heart failure (AHF) is unknown.METHODS:
Serum VEGF-C levels were measured in 237 patients hospitalized for AHF. The population was stratified by VEGF-C levels and linked with clinical signs of congestion and outcomes.RESULTS:
The study's population was divided in VEGF-C tertiles low (median [Q25-Q75] 33 [15-175]), medium (606 [468-741]) and high (1141 [968-1442] pg/mL). The group with low VEGF-C on admission presented with the highest prevalence of severe lower-extremity edema (low VEGF-C vs medium VEGF-C vs high VEGF-C) 30% vs 13% vs 20%; Pâ¯=â¯0.02); the highest percentage of patients with ascites 22% vs 9% vs 6%; Pâ¯=â¯0.006; and the lowest proportion of patients with pulmonary congestion 22% vs 30% vs 46%; Pâ¯=â¯0.004. The 1-year mortality rate was the highest in the low VEGF-C tertile 35% vs 28% vs 18%, respectively; Pâ¯=â¯0.049. The same pattern was observed for the composite endpoint (death and AHF rehospitalization) 45% vs 43% vs 26%; Pâ¯=â¯0.029. The risks of death at 1-year follow-up and composite endpoint were significantly lower in the high VEGF-C group.CONCLUSIONS:
Low VEGF-C was associated with more severe signs of congestion (signs of fluid accumulation) and adverse clinical outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edema Pulmonar
/
Insuficiência Cardíaca
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article