Bryostatin-1 attenuates intestinal ischemia/reperfusion-induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO-1 signaling.

Liu, Mulin; Wen, Hexin; Zuo, Lugen; Song, Xue; Geng, Zhijun; Ge, Sitang; Ge, Yuanyuan; Wu, Rong; Chen, Shiyuan; Yu, Chaowen; Gao, Yong

Liu, Mulin; Wen, Hexin; Zuo, Lugen; Song, Xue; Geng, Zhijun; Ge, Sitang; Ge, Yuanyuan; Wu, Rong; Chen, Shiyuan; Yu, Chaowen; Gao, Yong.

Afiliação

Liu M; Department of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Wen H; Department of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Zuo L; Department of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Song X; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Geng Z; Department of Central Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Ge S; Department of Central Laboratory, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Ge Y; Department of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Wu R; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China.
Chen S; Department of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yu C; Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Gao Y; Department of Vascular Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

FASEB J ; 37(6): e22948, 2023 06.

Article em En | MEDLINE | ID: mdl-37130016

Assuntos

Enteropatias; Traumatismo por Reperfusão; Animais; Humanos; Camundongos; Briostatinas/farmacologia; Células CACO-2; Inflamação/metabolismo; Enteropatias/prevenção & controle; Isquemia; Lipopolissacarídeos/farmacologia; Camundongos Endogâmicos C57BL; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo; Reperfusão; Traumatismo por Reperfusão/metabolismo

Palavras-chave

bryostatin-1; inflammation; intestinal barrier; intestinal ischemia-reperfusion injury; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Enteropatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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