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Non-Invasive Treatment of Basal Cell Carcinoma: Photodynamic Therapy Following Curettage.
J Drugs Dermatol ; 22(5): 481-485, 2023 May 01.
Article em En | MEDLINE | ID: mdl-37133481
ABSTRACT

BACKGROUND:

To investigate the effectiveness, safety, patient satisfaction, and cosmetic outcome of Methyl Aminolevulinate-Photodynamic Therapy (MAL-PDT) following curettage in order to make recommendations for its use in dermatology practices.

METHODS:

A retrospective chart review of patients who received MAL-PDT following curettage for the indication of basal cell carcinoma (BCC) between 2009 and 2016 at a single private clinic in Ontario, Canada. Two hundred and seventy-eight patients with 352 BCC lesions were included, consisting of 44.2% males (n=123) and 55.8% females (n=155) with a mean age of 57.24 years. The primary outcome measurement consisted of the cure rate. Secondary outcome measurements included side effects, patient satisfaction, and cosmetic outcome, as reported in the medical charts.

RESULTS:

The overall cure rate was 90.3% (n=318). After controlling for age, sex, and lesion type, nasal lesions were approximately 2.82 (95% CI 1.24-6.40, P=0.01) times more likely to experience a recurrence. 18.3% of patients (n=51) reported side effects, the most common being burning (n=19). Of those who expressed satisfaction, 100% (n=25) reported being happy. Of lesions with cosmetic data, 90.3% displayed a good response (n=149).

CONCLUSION:

MAL-PDT following curettage is an effective and safe treatment option for BCC lesions with a good cosmetic outcome and suggested high patient satisfaction. J Drugs Dermatol. 2023;22(5) doi10.36849/JDD.7133.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Neoplasias Cutâneas / Carcinoma Basocelular Tipo de estudo: Etiology_studies / Guideline / Observational_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Neoplasias Cutâneas / Carcinoma Basocelular Tipo de estudo: Etiology_studies / Guideline / Observational_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article