BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of ß-amyloid peptides.

Zhou, John; Singh, Neeraj; Galske, James; Hudobenko, Jacob; Hu, Xiangyou; Yan, Riqiang

Zhou, John; Singh, Neeraj; Galske, James; Hudobenko, Jacob; Hu, Xiangyou; Yan, Riqiang.

Afiliação

Zhou J; Department of Neuroscience, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-3401, USA.
Singh N; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44195, United States.
Galske J; Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, United States.
Hudobenko J; Department of Neuroscience, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-3401, USA.
Hu X; Department of Neuroscience, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-3401, USA.
Yan R; Department of Neuroscience, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-3401, USA.

Mol Neurodegener ; 18(1): 31, 2023 05 04.

Article em En | MEDLINE | ID: mdl-37143090

Assuntos

Doença de Alzheimer; Peptídeos beta-Amiloides; Animais; Camundongos; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Ácido Aspártico Endopeptidases/metabolismo; Astrócitos/metabolismo; Clusterina/metabolismo; Camundongos Knockout; Camundongos Transgênicos

Palavras-chave

Amyloid plaques; Aß clearance; BACE1; CXCL14; Clusterin; Insulin receptor; Reactive astrocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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