Neogenin expression in ependymo-radial glia of the larval sea lamprey Petromyzon marinus spinal cord.

ABSTRACT

Neogenin is a receptor mainly known for its roles during axon pathfinding. However, neogenin is expressed in neuronal precursors of ventricular and subventricular zones of the nervous system and recent work has shown that it regulates adult neurogenesis. Here, we generated an antibody against the sea lamprey neogenin to study its expression in the larval spinal cord. Immunofluorescence experiments show that neogenin is expressed in ependymo-radial glial cells (ERGs) located in the ependymal region of the central canal of mature larval sea lampreys. Our results provide a basis for the future study of the role of neogenin in lamprey ERGs.