Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression.

Finisguerra, Veronica; Dvorakova, Tereza; Formenti, Matteo; Van Meerbeeck, Pierre; Mignion, Lionel; Gallez, Bernard; Van den Eynde, Benoit J

Finisguerra, Veronica; Dvorakova, Tereza; Formenti, Matteo; Van Meerbeeck, Pierre; Mignion, Lionel; Gallez, Bernard; Van den Eynde, Benoit J.

Afiliação

Finisguerra V; de Duve Institute, UCLouvain, Brussels, Belgium benoit.vandeneynde@bru.licr.org veronica.finisguerra@uclouvain.be.
Dvorakova T; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
Formenti M; Walloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, Belgium.
Van Meerbeeck P; de Duve Institute, UCLouvain, Brussels, Belgium.
Mignion L; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
Gallez B; Walloon Excellence in Life Science and Biotechnology (WELBIO), WEL Research Institute, Brussels, Belgium.
Van den Eynde BJ; de Duve Institute, UCLouvain, Brussels, Belgium.

J Immunother Cancer ; 11(5)2023 05.

Article em En | MEDLINE | ID: mdl-37147018

Assuntos

Metformina; Neoplasias; Humanos; Animais; Camundongos; Metformina/farmacologia; Metformina/uso terapêutico; Neoplasias/tratamento farmacológico; Neoplasias/patologia; Linfócitos T CD8-Positivos; Imunoterapia; Terapia de Imunossupressão; Imunossupressores; Hipóxia; Microambiente Tumoral

Palavras-chave

immunotherapy; lymphocytes, tumor-infiltrating; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metformina / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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