Your browser doesn't support javascript.
loading
Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way.
He, Chun-Hui; Song, Ning-Ning; Xie, Pin-Xi; Wang, Yu-Bing; Chen, Jia-Yin; Huang, Ying; Hu, Ling; Li, Zhao; Su, Jun-Hui; Zhang, Xiao-Qing; Zhang, Lei; Ding, Yu-Qiang.
Afiliação
  • He CH; Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, and Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, 200092, China.
  • Song NN; Department of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
  • Xie PX; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
  • Wang YB; Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) and Department of Anatomy, Histology and Embryology, Tongji University School of Medicine, Shanghai, 200092, China.
  • Chen JY; Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai, 200092, China.
  • Huang Y; Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) and Department of Anatomy, Histology and Embryology, Tongji University School of Medicine, Shanghai, 200092, China.
  • Hu L; Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai, 200092, China.
  • Li Z; Department of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
  • Su JH; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
  • Zhang XQ; Department of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
  • Zhang L; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
  • Ding YQ; Department of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
Cell Death Dis ; 14(5): 309, 2023 05 06.
Article em En | MEDLINE | ID: mdl-37149633
To establish functional circuitry, neurons settle down in a particular spatial domain by spacing their cell bodies, which requires proper positioning of the soma and establishing of a zone with unique connections. Deficits in this process are implicated in neurodevelopmental diseases. In this study, we examined the function of EphB6 in the development of cerebral cortex. Overexpression of EphB6 via in utero electroporation results in clumping of cortical neurons, while reducing its expression has no effect. In addition, overexpression of EphrinB2, a ligand of EphB6, also induces soma clumping in the cortex. Unexpectedly, the soma clumping phenotypes disappear when both of them are overexpressed in cortical neurons. The mutual inhibitory effect of EphB6/ EphrinB2 on preventing soma clumping is likely to be achieved via interaction of their specific domains. Thus, our results reveal a combinational role of EphrinB2/EphB6 overexpression in controlling soma spacing in cortical development.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efrina-B2 / Receptor EphB6 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efrina-B2 / Receptor EphB6 Idioma: En Ano de publicação: 2023 Tipo de documento: Article