Your browser doesn't support javascript.
loading
Decreased emotion recognition and reduced focus on facial hallmarks in behavioral variant frontotemporal dementia compared to primary psychiatric disorders and controls.
Fieldhouse, Jay L P; Singleton, Ellen H; van Engelen, Marie-Paule E; Van't Hooft, Jochum J; de Boer, Sterre C M; Froeling, Violet E; Braun, Michelle; Oudega, Mardien L; van Grootheest, Daniël; Kerssens, Cora; Duits, Flora H; van Harten, Argonde C; Vijverberg, Everard G B; Pijnenburg, Yolande A L.
Afiliação
  • Fieldhouse JLP; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Singleton EH; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • van Engelen ME; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Van't Hooft JJ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • de Boer SCM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Froeling VE; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Braun M; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Oudega ML; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • van Grootheest D; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Kerssens C; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Duits FH; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • van Harten AC; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Vijverberg EGB; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Pijnenburg YAL; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Eur J Neurol ; 30(8): 2222-2229, 2023 08.
Article em En | MEDLINE | ID: mdl-37157190
BACKGROUND AND PURPOSE: Early diagnosis of behavioral variant frontotemporal dementia (bvFTD) is challenging due to symptomatic overlap with primary psychiatric disorders (PPD). As emotion recognition deficits are early and key features of bvFTD, the aim was to explore processes driving social cognition deficits that may aid in the differentiation between bvFTD and PPD. METHODS: The total sample (N = 51) included 18 patients with bvFTD, 11 patients with PPD (mood, autism spectrum and psychotic disorders) and 22 controls from the Alzheimer Center Amsterdam of the Amsterdam UMC. Emotion recognition was assessed with the Ekman 60 Faces test, during which eye tracking metrics were collected in the first 5 s a face was presented. Group differences in dwell time on the total image as well as the circumscribed eyes area and mouth area were analysed using ANOVA, with post hoc comparisons. RESULTS: Patients with bvFTD scored lowest, patients with PPD scored intermediate and controls scored highest on emotion recognition. During facial processing, patients with bvFTD spent less dwell time on the total image than controls (mean difference 11.3%, F(2, 48) = 6.095, p = 0.004; bvFTD-controls p = 0.001, 95% confidence interval [CI] -892.64, -239.70). Dwell time on the eyes area did not differ between diagnostic groups, whilst patients with bvFTD spent less dwell time on the mouth area than PPD patients (mean difference 10.7%; F(2, 48) = 3.423, p = 0.041; bvFTD-PPD p = 0.022, 95% CI -986.38, -79.47) and controls (mean difference 7.8%; bvFTD-controls p = 0.043, 95% CI -765.91, -12.76). CONCLUSIONS: In bvFTD, decreased emotion recognition may be related to reduced focus on facial hallmarks. These findings suggest a valuable role for biometrics in social cognition assessment and the differentiation between bvFTD and PPD.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article