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Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas.
Van den Bruel, Annick; Bijnens, Jacqueline; Van Haecke, Helena; Vander Poorten, Vincent; Dick, Catherine; Vauterin, Tom; De Geeter, Frank.
Afiliação
  • Van den Bruel A; Internal Medicine, Endocrinology, AZ Sint-Jan, Bruges, Belgium. annick.vandenbruel@azsintjan.be.
  • Bijnens J; Otorhinolaryngology-Head and Neck Surgery, AZ Sint Maarten, Mechelen, Belgium.
  • Van Haecke H; AZ Sint-Jan, Bruges, Belgium.
  • Vander Poorten V; Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Dick C; Section Head and Neck Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Vauterin T; Otorhinolaryngology-Head and Neck Surgery, AZ Sint-Jan, Bruges, Belgium.
  • De Geeter F; Otorhinolaryngology-Head and Neck Surgery, AZ Sint-Jan, Bruges, Belgium.
Sci Rep ; 13(1): 7568, 2023 05 09.
Article em En | MEDLINE | ID: mdl-37160895
We retrospectively evaluated how accurately preoperative imaging localizes parathyroid adenoma in superior versus inferior parathyroids. Over 6 years, 104 patients with primary hyperparathyroidism underwent parathyroid surgery in a single centre. Of these, 103 underwent ultrasound, 97 [99mTc]pertechnetate/MIBI SPECT/CT and 30 [18F]fluorocholine (FCH) PET/CT. One patient with a unilateral double adenoma was excluded from the analysis. Surgical findings with histopathologic confirmation of adenoma were used as the standard. Ultrasound misjudged 5 of 48 detected lower adenomas as upper, but 14 of 29 upper adenomas as lower (error rate 10 vs 48%, p = 0.0002). The corresponding error rates for [99mTc]pertechnetate/MIBI SPECT/CT were 3 versus 55% (p = 0.000014), and for [18F]FCH PET/CT 17 versus 36% (p = 0.26). Our results suggest that about half of the superior parathyroid adenomas which are detected, are erroneously assigned to the inferior position by both ultrasound and SPECT/CT imaging whereas the opposite mistake is significantly less frequent with ultrasound and SPECT/CT.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Paratireoides / Adenoma / Hiperparatireoidismo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Paratireoides / Adenoma / Hiperparatireoidismo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article