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The polyphenol EGCG directly targets intracellular amyloid-ß aggregates and promotes their lysosomal degradation.
Secker, Christopher; Motzny, Angelika Y; Kostova, Simona; Buntru, Alexander; Helmecke, Lucas; Reus, Laura; Steinfort, Robert; Brusendorf, Lydia; Boeddrich, Annett; Neuendorf, Nancy; Diez, Lisa; Schmieder, Peter; Schulz, Aline; Czekelius, Constantin; Wanker, Erich E.
Afiliação
  • Secker C; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Motzny AY; Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Kostova S; Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf, Düsseldorf, Germany.
  • Buntru A; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Helmecke L; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Reus L; Evotec SE, Hamburg, Germany.
  • Steinfort R; Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf, Düsseldorf, Germany.
  • Brusendorf L; Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf, Düsseldorf, Germany.
  • Boeddrich A; Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf, Düsseldorf, Germany.
  • Neuendorf N; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Diez L; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Schmieder P; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Schulz A; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Czekelius C; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
  • Wanker EE; Neuroproteomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
J Neurochem ; 166(2): 294-317, 2023 07.
Article em En | MEDLINE | ID: mdl-37165774
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article