Model Informed Development of SIM0295 in Patients with Gout and Hyperuricemia and Healthy Volunteers Using a Population Pharmacokinetics/ Pharmacodynamics Approach.

Chen, Yueting; Yang, Yang; Xu, Shansen; Wang, Chenyu; Shu, Pan; Zhang, Xiaoyu; Huang, Qin; Kim, Jin Sook; Jiao, Zheng

Chen, Yueting; Yang, Yang; Xu, Shansen; Wang, Chenyu; Shu, Pan; Zhang, Xiaoyu; Huang, Qin; Kim, Jin Sook; Jiao, Zheng.

Afiliação

Chen Y; Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang Y; Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China.
Xu S; Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China.
Wang C; Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shu P; Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China.
Zhang X; Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China.
Huang Q; Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China.
Kim JS; JW Pharmaceutical Corporation, Seoul, Korea, Republic of South.
Jiao Z; Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Expert Opin Investig Drugs ; 32(5): 441-450, 2023 May.

Article em En | MEDLINE | ID: mdl-37183631

Assuntos

Gota; Hiperuricemia; Humanos; Hiperuricemia/tratamento farmacológico; Ácido Úrico; Voluntários Saudáveis; Gota/tratamento farmacológico; Supressores da Gota/farmacologia

Palavras-chave

Population pharmacokinetics/pharmacodynamics; SIM0295; gout and hyperuricemia; human uric acid transporter 1; serum uric acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperuricemia / Gota Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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