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MiR-302a-3p reduces cisplatin resistance of esophageal squamous cell carcinoma cells by targeting EphA2.
Ren, Yali; Ju, Qianqian; Zhang, Jinlin; Gu, Wei; Du, Jin.
Afiliação
  • Ren Y; Department of Pharmacy, Nantong Health College of Jiangsu Province, Nantong, Jiangsu, China.
  • Ju Q; Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
  • Zhang J; Department of Pharmacy, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu, China.
  • Gu W; Department of Pharmacy, Nantong Health College of Jiangsu Province, Nantong, Jiangsu, China.
  • Du J; Department of Cardiothoracic Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
J Chemother ; 36(1): 72-81, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37198946
ABSTRACT
Platinum-based chemotherapy is a common clinical treatment for esophageal squamous cell carcinoma (ESCC), and chemoresistance is a major leading reason for cancer treatment failure. MiR-302a-3p is involved in the development of many diseases. Here, we investigated the role of miR-302a-3p in the cisplatin resistance of ESCC cells and explored its potential mechanism via molecular techniques. The expression of miR-302a-3p was significantly reduced, while the expressions of EphA2 were increased in ESCC tumor tissues and cells. EphA2 was one target gene of miR-302a-3p, and was negatively regulated by miR-302a-3p. By regulating EphA2, miR-302a-3p reduced the viability and promoted the apoptosis of ECA109 cells treated with cisplatin, suggesting that miR-302a-3p could enhance the sensitivity of ECA109 cells to cisplatin treatment by targeting EphA2. MiR-302a-3p plays an important role in reducing cisplatin resistance by inhibiting EphA2, suggesting that it may be a promising therapeutic strategy for cisplatin resistance in ESCC in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / MicroRNAs / Carcinoma de Células Escamosas do Esôfago Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / MicroRNAs / Carcinoma de Células Escamosas do Esôfago Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article