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Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.
Rocha, Savannah M; Kirkley, Kelly S; Chatterjee, Debotri; Aboellail, Tawfik A; Smeyne, Richard J; Tjalkens, Ronald B.
Afiliação
  • Rocha SM; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Kirkley KS; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
  • Chatterjee D; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
  • Aboellail TA; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Smeyne RJ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Tjalkens RB; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Glia ; 71(9): 2154-2179, 2023 09.
Article em En | MEDLINE | ID: mdl-37199240
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article