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Remdesivir use in severe and critical COVID-19 patients might be associated with lower incidence of arterial thrombotic events.
Lucijanic, Marko; Bistrovic, Petra; Jordan, Ana; Mihaljevic, Iva; Bukvic, Stela; Kovacevic, Stjepan; Ranilovic, Darjan; Sakota, Sara; Vlasac Glasnovic, Josipa; Delic-Brkljacic, Diana.
Afiliação
  • Lucijanic M; Hematology department, University hospital Dubrava, Zagreb, Croatia; School of Medicine University of Zagreb, Zagreb, Croatia. Electronic address: markolucijanic@yahoo.com.
  • Bistrovic P; Cardiology department, University hospital Dubrava, Zagreb, Croatia.
  • Jordan A; Cardiology department, University hospital Dubrava, Zagreb, Croatia.
  • Mihaljevic I; Neurology department, University hospital Dubrava, Zagreb, Croatia.
  • Bukvic S; Neurology department, University hospital Dubrava, Zagreb, Croatia.
  • Kovacevic S; Internal medicine department, General hospital dr. Josip Bencevic, Slavonski Brod, Croatia.
  • Ranilovic D; Pulmonology department, University hospital Dubrava, Zagreb, Croatia.
  • Sakota S; Intensive medicine department, University hospital Dubrava, Zagreb, Croatia.
  • Vlasac Glasnovic J; Hematology department, University hospital Dubrava, Zagreb, Croatia.
  • Delic-Brkljacic D; School of Medicine University of Zagreb, Zagreb, Croatia; Cardiology department, University hospital center Sisters of mercy, Zagreb, Croatia.
Am J Emerg Med ; 70: 41-45, 2023 08.
Article em En | MEDLINE | ID: mdl-37201450
INTRODUCTION: Venous thromboembolism (VTE) and arterial thrombotic (AT) events are a striking feature of severe COVID-19, however, relationship of remdesivir use and the risk of thrombotic events is unknown and has not been investigated before. METHODS: We retrospectively analyzed a cohort of 876 consecutive hospitalized severe and critical COVID-19 patients who were treated with remdesivir and compared them to 876 case-matched control patients. All patients were treated in our tertiary-level institution in period from 10/2020 to 6/2021. VTE and AT were diagnosed by objective imaging and laboratory methods. RESULTS: After exclusion of 71 VTE and 37 AT events present at the time of hospital admission, there were a total of 70 VTE (35 in the remdesivir and 35 in the control group) and 38 AT events occurring during hospitalization (13 in the remdesivir and 25 in the control group). There was a similar cumulative post-admission VTE incidence among both remdesivir and matched control patients (P = 0.287). Significantly lower cumulative post-admission AT incidence was observed among patients treated with remdesivir than among matched control patients (1.7% vs 3.3%, HR = 0.51, P = 0.035). Tendency for lower AT rates was evident in subgroups of patients stratified according to the type of AT, as well as according to the intensity of required oxygen supplementation at the time of remdesivir use. CONCLUSION: Remdesivir use in severe and critical COVID-19 patients might be associated with lower occurrence of AT during hospitalization, whereas similar rates of VTE events were observed among both patients treated with remdesivir and control patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Tromboembolia Venosa / COVID-19 Tipo de estudo: Incidence_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Tromboembolia Venosa / COVID-19 Tipo de estudo: Incidence_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article