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The Role of Cytomorphometric Image Analysis in the Diagnosis of Thyroid Nodules.
Chaurasia, Jai K; Ilyas, Abeer M; Walke, Vaishali; Gupta, Vikas; Kapoor, Neelkamal.
Afiliação
  • Chaurasia JK; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, IND.
  • Ilyas AM; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, IND.
  • Walke V; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, IND.
  • Gupta V; Otorhinolaryngology, All India Institute of Medical Sciences, Bhopal, IND.
  • Kapoor N; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, IND.
Cureus ; 15(4): e37872, 2023 Apr.
Article em En | MEDLINE | ID: mdl-37214005
ABSTRACT
Introduction Fine needle aspiration cytology (FNAC) plays a vital role in the diagnosis of thyroid nodules. However, it is challenging due to the heterogeneity of thyroid nodules, overlapping cytomorphological features, and interobserver variability. Cytomorphometric analysis turns subjective observations into quantitative values. In this study, we performed cytomorphometric image analysis on cytological smears of thyroid nodules, classified according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Materials and methods A retrospective analysis of Papanicolaou (PAP) and Hematoxylin & Eosin (H&E) stained fine needle aspirate smears from 50 patients with thyroid nodules with available follow-up histopathology was performed for a period of two years (March 2021 - March 2023), after obtaining approval from the institutional human ethical committee (IHEC-LOP/2020/IM0355). The nodules were categorized according to TBSRTC and were then subjected to cytomorphometric image analysis. Each nucleus was analyzed for 14 parameters, including aspect ratio, intensity, diameter, perimeter, roundness, area, fractal dimension, feret diameter, circularity, radii, fournier description, and chromatin texture parameters such as heterogeneity and clumpiness. The data obtained was analyzed through relevant statistical methods using SPSS version 23 (IBM Inc., Armonk, New York) and was compared by using the analysis of variance (ANOVA) test and post hoc test. Results Our results revealed that cytomorphometric image analysis not only distinguishes benign and malignant thyroid nodules but also can aid in categorizing thyroid nodules with predominant follicular patterns, such as follicular variant of papillary carcinoma, follicular adenoma and follicular carcinoma (p<0.001). Conclusions Morphometric analysis of cytological smears combined with cytomorphology has the potential to be an important tool in the diagnosis of thyroid nodules. It can improve diagnostic accuracy for better treatment and improved prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article