Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.

Suo, Jinlong; Shao, Rui; Yang, Ruici; Wang, Jinghui; Zhang, Zhong; Wang, Duo; Niu, Ningning; Zheng, Xianyou; Zou, Weiguo

Suo, Jinlong; Shao, Rui; Yang, Ruici; Wang, Jinghui; Zhang, Zhong; Wang, Duo; Niu, Ningning; Zheng, Xianyou; Zou, Weiguo.

Afiliação

Suo J; Institute of Microsurgery on Extremities and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China. suojinlong2015@sibcb.ac.cn.
Shao R; Institute of Microsurgery on Extremities and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China.
Yang R; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Wang J; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Zhang Z; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Wang D; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Niu N; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiao Tong University, 200127, Shanghai, China. niunn2014@outlook.com.
Zheng X; Institute of Microsurgery on Extremities and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China. zhengxianyou@126.com.
Zou W; Institute of Microsurgery on Extremities and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China. zouwg94@sibcb.ac.cn.

Cell Death Dis ; 14(5): 336, 2023 05 22.

Article em En | MEDLINE | ID: mdl-37217512

Assuntos

Cartilagem Articular; Osteoartrite; Progéria; Camundongos; Animais; Cartilagem Articular/metabolismo; Epigênese Genética; Metaloendopeptidases/metabolismo; Envelhecimento/genética; Progéria/genética; Senescência Celular/genética; Camundongos Knockout; Osteoartrite/genética; Lamina Tipo A/genética; Lamina Tipo A/metabolismo; Proteínas de Membrana/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Progéria / Cartilagem Articular Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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