Chromatin structure related to oncogenesis.
Cancer Sci
; 114(8): 3068-3075, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37218420
ABSTRACT
Chromatin is the fundamental structure of genomic DNA in eukaryotic cells. The nucleosome, the primary unit of chromatin, consists of DNA and histone proteins, and is important for the maintenance of genomic DNA. Histone mutations are present in many types of cancers, suggesting that chromatin and/or nucleosome structures could be closely related to cancer development. Histone modifications and histone variants are also involved in regulating chromatin and nucleosome structures. Chromatin structures are dynamically changed by nucleosome binding proteins. In this review article, we discuss the current progress toward understanding the relationship between chromatin structure and cancer development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Nucleossomos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article