Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database.

ABSTRACT

OBJECTIVE: To evaluate the association of triglyceride-glucose (TyG) index on admission with outcomes of critically ill patients. DESIGN: A retrospective study. SETTING: A population-based cohort study of Medical Information Mart for Intensive Care III Database (MIMIC III). PARTICIPANTS: All intensive care unit admissions were extracted from MIMIC III. MAIN OUTCOME MEASURES: The TyG index was calculated as ln [triglycerides (mg/dL)×glucose (mg/dL)/2]. The primary endpoint was 360-day mortality. RESULTS: A total of 3902 patients with an average age of 63.1±15.9 years old were enrolled, including 1623 (41.6%) women. The 360-day mortality was lower in a higher TyG group. Compared with the lowest TyG group, the HR of 360-day mortality was 0.79 (95% CI (0.66, 0.95); p=0.011) in the fully adjusted Cox model and 0.71 (95% CI (0.59, 0.85); p<0.001) in the stepwise Cox model. In the subgroup analysis, an interaction effect was detected between TyG index and gender. CONCLUSIONS: A lower TyG index was associated with the risk of 360-day mortality in critically ill patients, which could be a predictor of long-term survival of critically ill patients.