Your browser doesn't support javascript.
loading
COVID-19 pandemic and the quality of antibiotic use in primary care: an interrupted time-series study.
Domingues, Mariana; Torre, Carla; Guerreiro, José Pedro; Barata, Pedro; Correia-Neves, Margarida; Rocha, João; Sepodes, Bruno; Teixeira Rodrigues, António.
Afiliação
  • Domingues M; Departamento de Farmácia, Farmacologia e Tecnologias em Saúde, Faculdade de Farmácia da Universidade de Lisboa, Avenida Professor Gama Pinto, Lisboa 1649-003, Portugal.
  • Torre C; Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science-Research Institute for Medicines of the University of Lisbon (iMED.ULisboa), Avenida Professor Gama Pinto, Lisboa 1649-003, Portugal.
  • Guerreiro JP; Centre for Health Evaluation & Research (CEFAR-INFOSAUDE), National Association of Pharmacies (ANF), R. Mal. Saldanha 1, Lisboa 1249-069, Portugal.
  • Barata P; Centro Hospitalar Universitário do Porto (CHUPorto), Largo Prof. Abel Salazar, Porto 4099-001, Portugal.
  • Correia-Neves M; Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, Porto 4200-150, Portugal.
  • Rocha J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, Braga 4710-057, Portugal.
  • Sepodes B; ICVS/3B's-PT Government Associate Laboratory, University of Minho, Campus de Gualtar, Braga/Guimarães 4710-057, Portugal.
  • Teixeira Rodrigues A; Departamento de Farmácia, Farmacologia e Tecnologias em Saúde, Faculdade de Farmácia da Universidade de Lisboa, Avenida Professor Gama Pinto, Lisboa 1649-003, Portugal.
Int J Qual Health Care ; 35(2)2023 May 24.
Article em En | MEDLINE | ID: mdl-37226230
The coronavirus disease-19 pandemic and the related public health mitigation measures have impacted the transmission of infectious diseases; however, their impact on the use of antibacterials has not yet been extensively evaluated. This study evaluated the impact of the pandemic on the consumption patterns of antibacterials for systemic use in primary care in Portugal. An interrupted time-series analysis was performed using the autoregressive integrated moving average model of the antibacterials dispensed in the community pharmacies in Portugal from 1 January 2016 to 30 June 2022. Monthly rates of absolute consumption (all antibacterials for systemic use, and specifically penicillins; cephalosporins; macrolides, lincosamides, and streptogramins; and quinolones) and the relative consumption of antibacterials (penicillins sensitive to ß-lactamase, penicillin combinations including ß-lactamase inhibitors, third- and fourth-generation cephalosporins, fluoroquinolones, and the ratio of broad- to narrow-spectrum antibacterials) were estimated. Antibiotic consumption was expressed in defined daily doses per 1000 inhabitants per day (DID). In Portugal, the consumption of antibacterials (J01) declined sharply immediately after the beginning of the pandemic, having a significant reduction of >5 DID (P < .0001). A similar, short-term impact was found for penicillins (-2.920 DID; P < .0001); cephalosporins (-0.428 DID; P < .0001); macrolides, lincosamides, and streptogramins (-0.681 DID; P = .0021); and quinolones (-0.320 DID; P < .0001). A long-term increase was found for cephalosporins (+0.019 DID per month; P < .0001). Relative consumption changes were only found for third- and fourth-generation cephalosporins (0.0734%). Our study suggests that the coronavirus disease-19 pandemic may have resulted in a decrease in antibiotic use, with no significant changes in the relative dispense. Uncertainties regarding the long-term effects of the pandemic and its impact on the rates of resistance remain.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article