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Dysuricemia-A New Concept Encompassing Hyperuricemia and Hypouricemia.
Otani, Naoyuki; Ouchi, Motoshi; Mizuta, Einosuke; Morita, Asuka; Fujita, Tomoe; Anzai, Naohiko; Hisatome, Ichiro.
Afiliação
  • Otani N; Department of Cardiology, Dokkyo Medical University Nikkyo Medical Center, Nikko 321-1298, Tochigi, Japan.
  • Ouchi M; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu 321-0293, Tochigi, Japan.
  • Mizuta E; Department of Cardiology, Sanin Rosai Hospital, Yonago 683-8605, Tottori, Japan.
  • Morita A; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu 321-0293, Tochigi, Japan.
  • Fujita T; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu 321-0293, Tochigi, Japan.
  • Anzai N; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu 321-0293, Tochigi, Japan.
  • Hisatome I; Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Chiba, Japan.
Biomedicines ; 11(5)2023 Apr 23.
Article em En | MEDLINE | ID: mdl-37238926
The importance of uric acid, the final metabolite of purines excreted by the kidneys and intestines, was not previously recognized, except for its role in forming crystals in the joints and causing gout. However, recent evidence implies that uric acid is not a biologically inactive substance and may exert a wide range of effects, including antioxidant, neurostimulatory, proinflammatory, and innate immune activities. Notably, uric acid has two contradictory properties: antioxidant and oxidative ones. In this review, we present the concept of "dysuricemia", a condition in which deviation from the appropriate range of uric acid in the living body results in disease. This concept encompasses both hyperuricemia and hypouricemia. This review draws comparisons between the biologically biphasic positive and negative effects of uric acid and discusses the impact of such effects on various diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article