Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone-based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease.

Ezzat, Manal Abdel Fattah; Abdelhamid, Sara Mohamed; Fouad, Marwa A; Abdel-Aziz, Hatem A; Allam, Heba Abdelrasheed

Ezzat, Manal Abdel Fattah; Abdelhamid, Sara Mohamed; Fouad, Marwa A; Abdel-Aziz, Hatem A; Allam, Heba Abdelrasheed.

Afiliação

Ezzat MAF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abdelhamid SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Fouad MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abdel-Aziz HA; Pharmaceutical Chemistry Department, School of Pharmacy, Newgiza University, Cairo, Egypt.
Allam HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Giza, Egypt.

Drug Dev Res ; 84(6): 1231-1246, 2023 09.

Article em En | MEDLINE | ID: mdl-37243322

Assuntos

Doença de Alzheimer; Inibidores da Colinesterase; Camundongos; Animais; Inibidores da Colinesterase/farmacologia; Inibidores da Colinesterase/uso terapêutico; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Donepezila/farmacologia; Acetilcolinesterase/metabolismo; Simulação de Acoplamento Molecular; Cinética; Desenho de Fármacos; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's disease; acetylcholinesterase inhibitor; in vivo study; phthalazine derivative

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Colinesterase / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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