Diminished ovarian reserve in adolescent cancer survivors treated with heavy metal chemotherapy.
Pediatr Blood Cancer
; 70(8): e30448, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37243931
ABSTRACT
The extent to which heavy metal chemotherapy results in treatment-related ovarian damage is controversial. Anti-Mullerian hormone (AMH) levels measured more than 1 year after cancer therapy completion were abstracted from the medical records of 39 female survivors of childhood cancer aged 11 years and older, whose only gonadotoxic exposure was heavy metal chemotherapy. One-fifth of survivors who received cisplatin had AMH levels indicative of diminished ovarian reserve at last measurement. There was an observed clustering of low AMH in patients diagnosed in the peripubertal age range (i.e., 10-12 years). These findings may support a small, but present, risk of gonadal damage after heavy metal chemotherapy.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metais Pesados
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Reserva Ovariana
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Sobreviventes de Câncer
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Neoplasias
Limite:
Adolescent
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Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article