Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.
Brain
; 146(10): 4033-4039, 2023 10 03.
Article
em En
| MEDLINE
| ID: mdl-37249190
ABSTRACT
Melzak and Wall's gate control theory proposed that innocuous input into the dorsal horn of the spinal cord represses pain-inducing nociceptive input. Here we show that input from proprioceptive parvalbumin-expressing sensory neurons tonically represses nociceptor activation within dorsal root ganglia. Deletion of parvalbumin-positive sensory neurons leads to enhanced nociceptor activity measured with GCaMP3, increased input into wide dynamic range neurons of the spinal cord and increased acute and spontaneous pain behaviour, as well as potentiated innocuous sensation. Parvalbumin-positive sensory neurons express the enzymes and transporters necessary to produce vesicular GABA that is known to be released from depolarized somata. These observations support the view that gate control mechanisms occur peripherally within dorsal root ganglia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parvalbuminas
/
Células Receptoras Sensoriais
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article