Using artificial neural networks to accelerate flowsheet optimization for downstream process development.

Keulen, Daphne; van der Hagen, Erik; Geldhof, Geoffroy; Le Bussy, Olivier; Pabst, Martin; Ottens, Marcel

Keulen, Daphne; van der Hagen, Erik; Geldhof, Geoffroy; Le Bussy, Olivier; Pabst, Martin; Ottens, Marcel.

Afiliação

Keulen D; Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.
van der Hagen E; Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Geldhof G; GSK, Technical Research & Development-Microbial Drug Substance, Rixensart, Belgium.
Le Bussy O; GSK, Technical Research & Development-Microbial Drug Substance, Rixensart, Belgium.
Pabst M; Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.
Ottens M; Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.

Biotechnol Bioeng ; 2023 May 31.

Article em En | MEDLINE | ID: mdl-37256724

Palavras-chave

artificial neural networks; chromatography; downstream process development; flowsheet optimization; mechanistic modeling; model-based process optimization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article