Investigating the NRAS 5' UTR as a target for small molecules.

Balaratnam, Sumirtha; Torrey, Zachary R; Calabrese, David R; Banco, Michael T; Yazdani, Kamyar; Liang, Xiao; Fullenkamp, Christopher R; Seshadri, Srinath; Holewinski, Ronald J; Andresson, Thorkell; Ferré-D'Amaré, Adrian R; Incarnato, Danny; Schneekloth, John S

Balaratnam, Sumirtha; Torrey, Zachary R; Calabrese, David R; Banco, Michael T; Yazdani, Kamyar; Liang, Xiao; Fullenkamp, Christopher R; Seshadri, Srinath; Holewinski, Ronald J; Andresson, Thorkell; Ferré-D'Amaré, Adrian R; Incarnato, Danny; Schneekloth, John S.

Afiliação

Balaratnam S; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Torrey ZR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Calabrese DR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Banco MT; Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
Yazdani K; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Liang X; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Fullenkamp CR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Seshadri S; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Holewinski RJ; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD 21702, USA.
Andresson T; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD 21702, USA.
Ferré-D'Amaré AR; Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
Incarnato D; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands.
Schneekloth JS; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: schneeklothjs@mail.nih.gov.

Cell Chem Biol ; 30(6): 643-657.e8, 2023 06 15.

Article em En | MEDLINE | ID: mdl-37257453

Assuntos

Quadruplex G; Neuroblastoma; Humanos; Regiões 5' não Traduzidas/genética; RNA Mensageiro/genética; Linhagem Celular; Proteínas de Membrana/genética; GTP Fosfo-Hidrolases/genética

Palavras-chave

NRAS; RAS targeting; RNA G-quadruplex; RNA targeting; SMM screening strategy; small molecules

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quadruplex G / Neuroblastoma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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