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Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto, Satoru; Takahashi, Shinichi; Ito, Daisuke; Daté, Yugaku; Okada, Kensuke; Kato, Chris; Nakamura, Shiho; Ozawa, Fumiko; Chyi, Chai Muh; Nishiyama, Ayumi; Suzuki, Naoki; Fujimori, Koki; Kondo, Tosho; Takao, Masaki; Hirai, Miwa; Kabe, Yasuaki; Suematsu, Makoto; Jinzaki, Masahiro; Aoki, Masashi; Fujiki, Yuto; Sato, Yasunori; Suzuki, Norihiro; Nakahara, Jin; Okano, Hideyuki.
Afiliação
  • Morimoto S; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Takahashi S; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Neurology and Stroke, Saitama Medical University International Medical Center, Saitama 350-1298, Japan.
  • Ito D; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Daté Y; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Okada K; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kato C; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Nakamura S; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Ozawa F; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Chyi CM; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Keio University Global Research Institute, Tokyo 108-8345, Japan.
  • Nishiyama A; Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
  • Suzuki N; Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
  • Fujimori K; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kondo T; Research Center of Neurology, ONO Pharmaceutical Co., Ltd., Osaka 541-8564, Japan.
  • Takao M; Department of Clinical Laboratory, National Center of Neurology and Psychiatry (NCNP), Tokyo 187-0031, Japan; Department of Neurology, Mihara Memorial Hospital, Isesaki, Gunmma 372-0006, Japan.
  • Hirai M; Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kabe Y; Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Suematsu M; Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Jinzaki M; Department of Radiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Aoki M; Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
  • Fujiki Y; Keio University Hospital Clinical and Translational Research Center, Tokyo 160-8582, Japan.
  • Sato Y; Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Suzuki N; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Nakahara J; Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Okano H; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address: hidokano@keio.jp.
Cell Stem Cell ; 30(6): 766-780.e9, 2023 06 01.
Article em En | MEDLINE | ID: mdl-37267913
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Esclerose Lateral Amiotrófica Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Esclerose Lateral Amiotrófica Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article